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1. (WO2017032349) SALTS OF 5-FLUORO-3-PHENYL-2-[(1S)-1-(9H-PURIN-6-YLAMINO)PROPYL]QUINAZOLIN-4-ONE AND PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/032349 International Application No.: PCT/CZ2016/000087
Publication Date: 02.03.2017 International Filing Date: 10.08.2016
IPC:
C07D 473/34 (2006.01) ,A61K 31/52 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32
Nitrogen atom
34
attached in position 6, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
ZENTIVA , K.S. [CZ/CZ]; U Kabelovny 130 102 37 Praha 10, CZ
Inventors:
KISS, Violetta; HU
TOZICKOVA, Hana; CZ
TIEGER, Eszter; HU
TKADLECOVA, Marcela; CZ
DAMMER, Ondrej; CZ
GURGUT, Tomáš; CZ
Agent:
JIROTKOVA, Ivana; Rott, Ruzicka & Guttmann Vinohradska 37 120 00 Praha 2, CZ
Priority Data:
PV 2015-57526.08.2015CZ
Title (EN) SALTS OF 5-FLUORO-3-PHENYL-2-[(1S)-1-(9H-PURIN-6-YLAMINO)PROPYL]QUINAZOLIN-4-ONE AND PREPARATION THEREOF
(FR) SELS DE 5-FLUORO-3-PHÉNYL-2-[(1S)-1-(9H-PURIN-6-YLAMINO)PROPYL]QUINAZOLIN-4-ONE ET PRÉPARATION DE CES DERNIERS
Abstract:
(EN) The present invention relates to salts of 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6- ylamino)propyl]quinazolin-4-one of Formula I and at least one acid component wherein the acid component is preferably selected from the group consisting of benzenesulphonic acid, methanesulphonic acid, hydrobromic acid, hydrochloric acid, hydroiodic acid, phosphoric acid and sulfuric acid and wherein the salt of Formula I and acid component is presented in a crystalline or an amorphous form. The invention also relates to processes of preparation of salts as well as to their use in pharmaceutical compositions. (I)
(FR) La présente invention concerne des sels de 5-fluoro-3-phényl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4-one de Formule I comprenant au moins un constituant acide. Le constituant acide est, de préférence, choisi dans le groupe constitué par l'acide benzène sulfonique, l'acide méthane sulfonique, l'acide bromhydrique, l'acide chlorhydrique, l'acide iodhydrique, l'acide phosphorique et l'acide sulfurique. Le sel de Formule I et le constituant acide sont présents sous une forme cristalline ou amorphe. L'invention concerne également des procédés de préparation des sels ainsi que leur utilisation dans des compositions pharmaceutiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)