Search International and National Patent Collections

1. (WO2017032281) NOVEL CRYSTAL FORMS OF PANOBINOSTAT LACTATE

Pub. No.:    WO/2017/032281    International Application No.:    PCT/CN2016/096075
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 20 01:59:59 CEST 2016
IPC: C07D 209/14
A61K 31/4045
A61P 35/00
Applicants: CRYSTAL PHARMATECH CO., LTD.
苏州晶云药物科技有限公司
Inventors: CHEN, Minhua
陈敏华
ZHANG, Yanfeng
张炎锋
LI, Jiaoyang
李骄洋
ZHANG, Xiaoyu
张晓宇
Title: NOVEL CRYSTAL FORMS OF PANOBINOSTAT LACTATE
Abstract:
Provided are novel crystal forms of panobinostat lactate, named a crystal form G, a crystal form H, and a crystal form I, respectively. An X-ray powder diffraction pattern of the crystal form G has a characteristic peak at a 2theta value 7.7°±0.2°, 20.0°±0.2°, and 10.3°±0.2°. An X-ray powder diffraction pattern of the crystal form H has a characteristic peak at a 2theta value 11.8°±0.2°, 21.0°±0.2°, and 15.0°±0.2°. An X-ray powder diffraction pattern of the crystal form I has a characteristic peak at a 2theta value 10.2°±0.2°, 25.0°±0.2°, and 22.9°±0.2°. The provided three novel crystal forms of panobinostat lactate can assist a researcher in understanding and controlling heteromorphism of the panobinostat lactate, thereby facilitating preparation of a medicine which is more effective or more stable.