Search International and National Patent Collections

1. (WO2017032277) BOVINE LUNG ENOXAPARIN SODIUM, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Pub. No.:    WO/2017/032277    International Application No.:    PCT/CN2016/096026
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 20 01:59:59 CEST 2016
IPC: C08B 37/10
A61P 7/02
Applicants: SUZHOU RONNSI PHARMA CO., LTD.
苏州融析生物科技有限公司
Inventors: JIN, Yongsheng
金永生
JIN, Caijuan
靳彩娟
YAO, Yiming
姚亦明
Title: BOVINE LUNG ENOXAPARIN SODIUM, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Abstract:
Provided are a bovine lung enoxaparin sodium, a preparation method therefor, and an application thereof. The bovine lung enoxaparin sodium is prepared from bovine lung heparin, and the content of ΔUA2S-GlcNS6S(ΔⅠS) is up to 75% to 83%, while the content of the ΔⅠS in (bovine intestinal mucosa) enoxaparin sodium, sheep intestinal mucosa enoxaparin sodium, and bovine lung enoxaparin sodium is respectively 58% to 66%, 64% to 72%, and 50% to 58% only. The biological anticoagulant activity, anti-Xa, anti-Ⅱa, the ratio between the anti-Xa and the anti-Ⅱa, and other physiochemical properties of the bovine lung enoxaparin sodium all meet the release criteria of the current pharmacopeia to enoxaparin sodium. Also provided are two types of bovine lung enoxaparin sodium injections, preparation methods therefor, and applications in anticoagulation experiments inside animals.