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|1. (WO2017032275) SHEEP ENOXAPARIN SODIUM, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF|
|Applicants:||SUZHOU RONNSI PHARMA CO., LTD.
|Title:||SHEEP ENOXAPARIN SODIUM, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF|
Provided are sheep enoxaparin sodium, a preparation method therefor, and an application thereof. The sheep enoxaparin sodium is prepared from sheep heparin. Compared with enoxaparin sodium that derives from porcine intestinal mucosa heparin and is stipulated by pharmacopeias such as the USP 37 and the EP 8.0, in addition to different sources, the chemical structures (being formed by a disaccharide) and the physiochemical properties are different to some extent. By means of optimization, refining, and grading of the preparation technology, the sheep enoxaparin sodium can meet the enoxaparin sodium quality release criteria in the USP 37 and the EP 8.0 except the provenance, and can totally meet that in current editions of the USP 39 and the EP 8.6. Also provided are two types of sheep enoxaparin sodium injections, preparation methods therefor, and applications in anticoagulation experiments inside animals. A raw material of the sheep enoxaparin sodium derives from sheep, and has the halal property that is not owned by porcine enoxaparin sodium. The sheep enoxaparin sodium and the injections thereof can be applied to anticoagulant, anti-thrombus, and halal medicine.