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1. (WO2017032236) COMPLEX PREPARED FROM ANTIMICROBIAL PEPTIDES IN COMBINATION WITH POLYMERS, AND PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2017/032236    International Application No.:    PCT/CN2016/095471
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Wed Aug 17 01:59:59 CEST 2016
IPC: A61K 38/16
A61K 38/08
A61K 38/10
A61K 47/42
A61P 31/04
A61P 31/10
A61P 31/12
Applicants: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA
中国人民解放军军事医学科学院毒物药物研究所
Inventors: LIU, Keliang
刘克良
WANG, Chenhong
王晨宏
QIE, Jiankun
郄建坤
FENG, Siliang
冯思良
Title: COMPLEX PREPARED FROM ANTIMICROBIAL PEPTIDES IN COMBINATION WITH POLYMERS, AND PREPARATION METHOD AND USE THEREOF
Abstract:
Provided in the present invention are a complex prepared from antimicrobial peptides in combination with polymers, the preparation method of the complex, and the use of the complex for preparing drugs for preventing or treating diseases or infections caused by bacteria (such as gram-positive bacteria or gram-negative bacteria), fungi or viruses. While the complex of the present invention maintains the antimicrobial peptide activity, the hemolytic toxicity thereof significantly decreases.