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1. (WO2017032201) MICRORNA-328 ANTI-SENSE COMPOSITION AND THERAPEUTIC USE

Pub. No.:    WO/2017/032201    International Application No.:    PCT/CN2016/092060
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Jul 29 01:59:59 CEST 2016
IPC: C12N 15/113
A61K 31/711
A61K 31/712
A61P 27/10
Applicants: KAOHSIUNG MEDICAL UNIVERSITY
Inventors: JUO, Suh-Hang H.
HSI, Edward
LIANG, Chung-Ling
Title: MICRORNA-328 ANTI-SENSE COMPOSITION AND THERAPEUTIC USE
Abstract:
Provided are oligodeoxyribonucleotides, or locked nucleic acid (LNA) -modified, and phosphorothioated (PS) bond-modified oligonucleotides directing to anti-sense microRNA-328. Also provided is a pharmaceutical composition comprising the anti-sense microRNA-328 composition and a pharmaceutically acceptable carrier. Further provided is a method for preventing or treating myopia by administering to a subject the anti-sense microRNA-328 composition.