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1. (WO2017031918) LONG-ACTING DIPEPTIDYL PEPTIDASE-IV INHIBITOR, APPLICATIONS, AND PREPARATION METHOD FOR INTERMEDIATE THEREOF
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Pub. No.: WO/2017/031918 International Application No.: PCT/CN2016/000478
Publication Date: 02.03.2017 International Filing Date: 23.08.2016
IPC:
C07D 471/04 (2006.01) ,C07D 405/04 (2006.01) ,A61K 31/519 (2006.01) ,A61K 31/4985 (2006.01) ,A61K 31/437 (2006.01) ,A61K 31/4035 (2006.01) ,A61P 3/10 (2006.01) ,A61P 3/04 (2006.01) ,A61P 3/06 (2006.01) ,A61P 5/50 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
4035
Isoindoles, e.g. phthalimide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
06
Antihyperlipidemics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
48
of the pancreatic hormones
50
for increasing or potentiating the activity of insulin
Applicants:
四川科伦药物研究院有限公司 SICHUAN KELUN PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. [CN/CN]; 中国四川省成都市 温江区海峡两岸科技产业开发园新华大道二段666号 No.666, Xinhua Avenue (Section 2), Hai Xia Industrial Park, Wenjiang District Chengdu, Sichuan 611138, CN
Inventors:
谢益农 XIE, Yinong; CN
游泽金 YOU, Zejin; CN
何云 HE, Yun; CN
宋占波 SONG, Zhanbo; CN
王亚军 WANG, Yajun; CN
张绍华 ZHANG, Shaohua; CN
李路 LI, Lu; CN
王浩东 WANG, Haodong; CN
张继超 ZHANG, Jichao; CN
朱军 ZHU, Jun; CN
曾宏 ZENG, Hong; CN
宋宏梅 SONG, Hongmei; CN
齐伟 QI, Wei; CN
王利春 WANG, Lichun; CN
王晶翼 WANG, Jingyi; CN
Agent:
中国专利代理(香港)有限公司 CHINA PATENT AGENT (H.K.) LTD.; CN
Priority Data:
201510521997.X24.08.2015CN
Title (EN) LONG-ACTING DIPEPTIDYL PEPTIDASE-IV INHIBITOR, APPLICATIONS, AND PREPARATION METHOD FOR INTERMEDIATE THEREOF
(FR) INHIBITEUR DE DIPEPTIDYL-PEPTIDASE-IV À ACTION PROLONGÉE, SES APPLICATIONS, ET UN PROCÉDÉ DE PRÉPARATION D'UN INTERMÉDIAIRE DE CELUI-CI
(ZH) 长效二肽基肽酶-IV抑制剂、用途及其中间体的制备方法
Abstract:
(EN) The present invention relates to a long-acting dipeptidyl peptidase-IV inhibitor, applications, and a preparation method for an intermediate thereof. Specifically, the present invention relates to a compound represented by general formula (1) and a preparation method therefor, applications of the compound in treating and preventing diseases comprising diabetes mellitus and diseases related to DPP-4 of the type II diabetes mellitus, and a pharmaceutical composition and a pharmaceutical preparation comprising the compound represented by general formula (1), definitions of symbols in the general formula being same as those in the descriptions.
(FR) La présente invention concerne un inhibiteur de dipeptidyl-peptidase-IV à action prolongée, ses applications, et un procédé de préparation d'un intermédiaire de celui-ci. Spécifiquement, la présente invention concerne un composé de formule générale (1) et son procédé de préparation, des applications du composé dans le traitement et la prévention de maladies comprenant le diabète sucré et les maladies associées à la DPP-4 du diabète de type 2, ainsi qu'une composition pharmaceutique et une préparation pharmaceutique comprenant le composé de formule générale (1), les définitions des symboles dans la formule générale étant identiques à celles figurant dans la description.
(ZH) 涉及长效二肽基肽酶-IV抑制剂、用途及其中间体的制备方法,具体地,涉及以下通式(1)所示的化合物及其制备方法、所述化合物在治疗和预防包括糖尿病、尤其是II 型糖尿病的DPP-4 相关疾病中的应用,以及含有所述通式(1)化合物的药物组合物和药物制剂,通式中各符号的定义与说明书中的相同。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)