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1. (WO2017031914) PHARMACEUTICAL COMPOSITION OF IBRUTINIB

Pub. No.:    WO/2017/031914    International Application No.:    PCT/CN2016/000443
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Thu Aug 11 01:59:59 CEST 2016
IPC: A61K 31/519
A61K 31/427
A61K 31/496
A61K 31/5377
A61P 35/00
Applicants: TAIZHOU HUAYUAN MEDICINAL TECH CO LTD
泰州华元医药科技有限公司
Inventors: WANG, Jianming
王建明
YANG, Jiajun
杨家俊
WANG, Jinjing
王进京
Title: PHARMACEUTICAL COMPOSITION OF IBRUTINIB
Abstract:
The present invention provides a pharmaceutical composition comprising ibrutinib and CYP3A enzyme inhibitor, wherein the CYP3A enzyme inhibitor is ritonavir, ketoconazole or cobicistat. The present invention also provides a use of said pharmaceutical composition in the manufacture of anti-tumor medicaments.