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1. (WO2017031899) POROUS CALCIUM PHOSPHATE MICROSPHERE MATERIAL HAVING BIG SURFACE HOLES, AND PREPARATION METHOD AND APPLICATIONS

Pub. No.:    WO/2017/031899    International Application No.:    PCT/CN2015/099636
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Wed Dec 30 00:59:59 CET 2015
IPC: A61L 27/12
A61L 27/56
A61K 47/04
A61K 9/16
Applicants: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
华南理工大学
Inventors: YE, Jiandong
叶建东
LI, Haiyan
李海燕
LI, Jiyan
李继彦
Title: POROUS CALCIUM PHOSPHATE MICROSPHERE MATERIAL HAVING BIG SURFACE HOLES, AND PREPARATION METHOD AND APPLICATIONS
Abstract:
A porous calcium phosphate microsphere material having big surface holes, and a preparation method thereof and applications thereof. The preparation method comprises the following steps: (1) dissolving polysaccharide gum in deionized water to prepare a polysaccharide gum solution; (2) dissolving a thickener in deionized water to prepare a thickener solution; (3) mixing the polysaccharide gum solution with the thickener solution to obtain a polysaccharide gum/thickener solution; (4) mixing calcium phosphate bone cement powder with the polysaccharide gum/thickener solution to obtain calcium phosphate bone cement slurry; and (5), stirring the calcium phosphate bone cement slurry at a high speed, conducting ultrasonic treatment, dropwise adding the slurry to liquid nitrogen, and conducting curing and vacuum drying on refrigerated microspheres to obtain porous calcium phosphate microspheres having big surface holes.