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1. (WO2017031839) L-ASPARAGINASE MUTANT WITH IMPROVED ENZYME ACTIVITY AND CONSTRUCTION METHOD THEREOF

Pub. No.:    WO/2017/031839    International Application No.:    PCT/CN2015/094554
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Nov 14 00:59:59 CET 2015
IPC: C12N 9/82
A23L 5/10
A61K 38/50
A61P 35/02
C12N 1/21
C12N 15/52
Applicants: JIANGNAN UNIVERSITY
江南大学
Inventors: RAO, Zhiming
饶志明
LONG, Shuiqing
龙水清
ZHANG, Xian
张显
YANG, Taowei
杨套伟
XU, Meijuan
徐美娟
Title: L-ASPARAGINASE MUTANT WITH IMPROVED ENZYME ACTIVITY AND CONSTRUCTION METHOD THEREOF
Abstract:
Provided are an L-asparaginase mutant with improved enzyme activity and a construction method thereof, wherein the mutant is constructed on the basis of the amino acid sequence as shown in the SEQ ID NO.2, in which glycine at position 107 is mutated into aspartic acid. Also provided is a genetically-engineered bacteria expressing the L-asparaginase mutant.