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1. WO2017029523 - ASSAY DEVICE

Publication Number WO/2017/029523
Publication Date 23.02.2017
International Application No. PCT/GB2016/052586
International Filing Date 19.08.2016
IPC
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 21/84 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
84Systems specially adapted for particular applications
CPC
B01L 2300/0636
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0627Sensor or part of a sensor is integrated
0636Integrated biosensor, microarrays
B01L 2300/0654
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0627Sensor or part of a sensor is integrated
0654Lenses; Optical fibres
B01L 2300/0825
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0809rectangular shaped
0825Test strips
B01L 2300/0887
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0887Laminated structure
B01L 2400/0406
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2400Moving or stopping fluids
04Moving fluids with specific forces or mechanical means
0403specific forces
0406capillary forces
B01L 3/5023
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5023with a sample being transported to, and subsequently stored in an absorbent for analysis
Applicants
  • MOLECULAR VISION LIMITED [GB]/[GB]
  • CAMBRIDGE DISPLAY TECHNOLOGY LIMITED [GB]/[GB]
Inventors
  • HAND, Chris
  • HOFMANN, Oliver
  • RYU, Gihan
  • RAMON, Miguel
  • BENZIE, Philip, William
  • KAY, Christopher John
Agents
  • BAILEY, Jennifer, Ann
Priority Data
1514730.919.08.2015GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ASSAY DEVICE
(FR) DISPOSITIF DE DOSAGE
Abstract
(EN)
An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample. The device comprises a lateral flow membrane (46) comprising a plurality of test regions (41A, 41B) and formed from a light transmissive material, a plurality (44A, 44B) of planar organic light emitting diode (OLED) emitters comprising an emission layer of an organic electroluminescent material, and a plurality (49A, 49B) of planar organic photodetectors (OPDs) comprising an absorption layer of an organic photovoltaic material. Each test region comprises an immobilised component for retaining analyte tagging particles. Each test region is aligned with the emission layer of one emitter and the absorption layer of one photodetector. The aligned emitter, photodetector, and test region form a group such that the emitter is capable of illuminating the test region and the photodetector is capable of detecting light from the test region. For each group, under conditions where the test region is wet and devoid of tagging particles the energised photodetector photocurrent that is produced is denoted il, when the group emitter is the only emitter that is energised, and Ί2 when the emitter of another group is additionally energised. Cross-talk (C), is then represented by the black arrows, and is defined according to the equation: C = 20 log10 (İ1 / (İ2 - İ1)) C is arranged to be greater than about 20dB for at least one group of the device.
(FR)
Cette invention concerne un dispositif de dosage pour la détermination quantitative de la concentration d'au moins un analyte dans un échantillon liquide. Le dispositif comprend une membrane à flux latéral (46) comprenant une pluralité de régions d'essai (41A, 41B) et formée à partir d'un matériau transmettant la lumière, une pluralité (44A, 44B) d'émetteurs plans de type diode électroluminescente organique (OLED) comprenant une couche d'émission à base d'un matériau électroluminescent organique, et une pluralité (49A, 49B) de photodétecteurs organiques (OPD) plans comprenant une couche d'absorption à base d'un matériau photovoltaïque organique. Chaque région d'essai comprend un composant immobilisé pour retenir les particules de marquage d'analyte. Chaque région d'essai est alignée avec la couche d'émission d'un émetteur et la couche d'absorption d'un photodétecteur. L'émetteur, le photodétecteur, et la région d'essai alignés forment un groupe tel que l'émetteur est capable d'éclairer la région d'essai et que le photodétecteur est capable de détecter la lumière émanant de la région d'essai. Pour chaque groupe, dans des conditions où la région d'essai est humide et dépourvue de particules de marquage, le photocourant du photodétecteur excité qui est produit est noté I1 quand l'émetteur du groupe est le seul émetteur à être excité, et Ί2 quand l'émetteur d'un autre groupe est en plus excité. La diaphonie (C) est ensuite représentée par les flèches noires, et est définie selon l'équation : C = 20 log10 (İ 1/(İ 2 - İ 1)) où la diaphonie C est agencée pour être supérieure à environ 20 dB pour au moins un groupe du dispositif.
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