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1. WO2017027459 - GLUCOSE CONTROL SYSTEM WITH AUTOMATIC ADAPTATION OF GLUCOSE TARGET

Publication Number WO/2017/027459
Publication Date 16.02.2017
International Application No. PCT/US2016/046008
International Filing Date 08.08.2016
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
CPC
A61B 5/14532
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
14532for measuring glucose, e.g. by tissue impedance measurement
A61B 5/4839
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
48Other medical applications
4836Diagnosis combined with treatment in closed-loop systems or methods
4839combined with drug delivery
A61B 5/7275
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
72Signal processing specially adapted for physiological signals or for diagnostic purposes
7271Specific aspects of physiological measurement analysis
7275Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
A61M 2005/14208
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
14208with a programmable infusion control system, characterised by the infusion program
A61M 5/1723
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; ; Monitoring media flow to the body
172electrical or electronic
1723using feedback of body parameters, e.g. blood-sugar, pressure
G16H 50/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
30for calculating health indices; for individual health risk assessment
Applicants
  • TRUSTEES OF BOSTON UNIVERSITY [US]/[US]
  • THE GENERAL HOSPITAL CORPORATION [US]/[US]
Inventors
  • EL-KHATIB, Firas
  • DAMIANO, Edward
  • RUSSELL, Steven J.
Agents
  • THOMPSON, James F.
Priority Data
62/202,50507.08.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GLUCOSE CONTROL SYSTEM WITH AUTOMATIC ADAPTATION OF GLUCOSE TARGET
(FR) SYSTÈME DE RÉGULATION DE GLUCOSE À ADAPTATION AUTOMATIQUE DE CIBLE DE GLUCOSE
Abstract
(EN)
A glucose control system employs adaptation of a glucose target (set-point) control variable in controlling delivery of insulin to a subject to maintain euglycemia. The glucose target adapts based on trends in actual glucose level (e.g., measured blood glucose in the subject), and/or computed doses of a counter-regulatory agent such as glucagon. An adaptation region with upper and lower bounds for the glucose target may be imposed. Generally the disclosed techniques can provide for robust and safe glucose level control. Adaptation may be based on computed doses of a counter-regulatory agent whether or not such agent is actually delivered to the subject, and may be used for example to adjust operation in a bihormonal system during periods in which the counter-regulatory agent is not available for delivery.
(FR)
L'invention concerne un système de régulation de glucose qui utilise l'adaptation d'une variable de régulation de cible de glucose (point de consigne) pour commander l'administration d'insuline à un sujet pour maintenir l'euglycémie. La cible de glucose s'adapte sur la base de tendances de niveau de glucose réel (par exemple la glycémie mesurée chez le sujet) et/ou de doses calculées d'un agent de régulation antagoniste tel que le glucagon. Une région d'adaptation, ayant des limites supérieure et inférieure pour la cible de glucose, peut être imposée. En général, les techniques de l'invention peuvent fournir une régulation robuste et sûre du niveau de glucose. L'adaptation peut se faire sur la base de doses calculées d'un agent de régulation antagoniste, qu'un tel agent soit réellement administré au sujet ou non, et peut être utilisée par exemple pour ajuster le fonctionnement d'un système bi-hormonal pendant des périodes durant lesquelles l'agent de régulation antagoniste n'est pas disponible pour une administration.
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