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1. WO2017024440 - CHIMERIC ANTIGEN RECEPTOR CONTAINING INTRACELLULAR DOMAIN OF TOLL-LIKE RECEPTOR

Publication Number WO/2017/024440
Publication Date 16.02.2017
International Application No. PCT/CN2015/086352
International Filing Date 07.08.2015
IPC
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C07K 16/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C12N 15/63 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/5156
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5156expressing foreign proteins
A61K 2039/5158
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5158Antigen-pulsed cells, e.g. T-cells
A61K 2039/804
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
804Blood cells [leukemia, lymphoma]
A61K 2039/86
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
86Lung
A61K 39/0011
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
Applicants
  • 深圳市体内生物医药科技有限公司 SHENZHEN IN VIVO BIOMEDICINE TECHNOLOGY LIMITED COMPANY [CN]/[CN]
Inventors
  • 李鹏 LI, Peng
  • 赖允鑫 LAI, Yunxin
  • 林思妙 LIN, Simiao
  • 姚瑶 YAO, Yao
Agents
  • 北京品源专利代理有限公司 BEYOND ATTORNEYS AT LAW
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CHIMERIC ANTIGEN RECEPTOR CONTAINING INTRACELLULAR DOMAIN OF TOLL-LIKE RECEPTOR
(FR) RÉCEPTEUR CHIMÈRE D'ANTIGÈNE CONTENANT UN DOMAINE INTRACELLULAIRE DU RÉCEPTEUR DE TYPE TOLL
(ZH) 含Toll样受体胞内结构域的嵌合抗原受体
Abstract
(EN)
Provided are a chimeric antigen receptor, coding nucleic acid and expression cell thereof, and use thereof in preparation of a tumor-treating drug. An intracellular domain of the chimeric antigen receptor at least comprises an intracellular domain of a toll-like receptor 1 and/or an intracellular domain of a toll-like receptor 2.
(FR)
L'invention concerne un récepteur chimère d'antigène, un acide nucléique codant et son expression cellulaire et son utilisation dans la préparation d'un médicament de traitement tumoral. Un domaine intracellulaire du récepteur chimère d'antigène comprend au moins un domaine intracellulaire d'un récepteur de type Toll 1 et/ou un domaine intracellulaire d'un récepteur de type Toll 2.
(ZH)
本发明提供了一种嵌合抗原受体、其编码核酸和表达细胞,以及其在制备治疗肿瘤的药物中的用途。所述嵌合抗原受体的胞内结构域至少包括Toll样受体1和/或Toll样受体2的胞内结构域。
Also published as
CN201580000296.X
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