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1. (WO2017024310) PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF USEFUL AS ANTIVIRAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/024310 International Application No.: PCT/US2016/046056
Publication Date: 09.02.2017 International Filing Date: 08.08.2016
IPC:
C07H 19/16 (2006.01) ,A61K 31/06 (2006.01) ,A61K 31/7076 (2006.01) ,A61P 31/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols
06
the aromatic ring being substituted by nitro groups
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7076
containing purines, e.g. adenosine, adenylic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
CHIMERIX, INC. [US/US]; 2505 Meridian Parkway Suite 340 Durham, North Carolina 27713, US
THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; Office of Technology Transfer 1600 Huron Pkwy., Building 520, 2nd Floor Ann Arbor, Michigan 48109, US
Inventors:
TOWNSEND, Leroy; US
DRACH, John; US
WARE, Roy W.; US
BOUGHER, John Henry, III; US
CHANGALVALA, Ramamurty V S; US
DOWNEY, Aaron Leigh; US
LANIER, Ernest Randall, Jr.; US
MCIVER, Andrew Louis; US
ROBERTSON, Bradley David; US
SELLESETH, Dean Wallace; US
SETHNA, Phiroze Behram; US
Agent:
ERLACHER, Heidi A.; US
ELRIFI, Ivor. R; US
Priority Data:
1606645.815.04.2016GB
62/202,01006.08.2015US
Title (EN) PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF USEFUL AS ANTIVIRAL AGENTS
(FR) NUCLÉOSIDES DE PYRROLOPYRIMIDINE ET ANALOGUES DE CEUX-CI UTILES EN TANT QU'AGENTS ANTIVIRAUX
Abstract:
(EN) The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
(FR) La présente invention concerne des analogues de nucléosides de pyrrolopyrimidine de formule I, formule IA, formule IB ou formule II et des conjugués de phospholipide et des compositions pharmaceutiques de ceux-ci, dans lesquels Rc et A sont tels que définis dans la description. L'invention concerne en outre des procédés de traitement et/ou e prévention d'une infection virale et/ou d'une maladie ou un trouble associé à une infection virale avec un ou plusieurs composés de formule I, formule IA, formule IB ou formule II.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)