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4. WO2017024131 - INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS, AND NON-NATURAL NKG2D LIGANDS THAT BIND NON-NATURAL NKG2D RECEPTORS

Publication Number WO/2017/024131
Publication Date 09.02.2017
International Application No. PCT/US2016/045550
International Filing Date 04.08.2016
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
74
Major histocompatibility complex (MHC)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
32
against translation products from oncogenes
C07K 16/28 (2006.01)
C07K 14/74 (2006.01)
C07K 14/47 (2006.01)
C12N 5/0783 (2010.01)
C07K 16/32 (2006.01)
CPC
C07K 14/7056
C07K 16/28
C07K 16/2863
C07K 16/30
C07K 2317/622
C07K 2317/94
Applicants
  • AVIDBIOTICS CORP. [US/US]; 100 Kimball Way South San Francisco, CA 94080, US
Inventors
  • LANDGRAF, Kyle; US
  • STEIGER, Daniel, P.; US
  • BARON, Tarah; US
  • GEBHART, Dana; US
Agents
  • MACK, Susan; US
  • TOWNSLEY, Alan; US
  • BIRD, John; US
Priority Data
62/200,94904.08.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS, AND NON-NATURAL NKG2D LIGANDS THAT BIND NON-NATURAL NKG2D RECEPTORS
(FR) FRAGMENTS D'ANTICORPS VARIABLES ET INSÉRABLES ET DOMAINES A1-A2 MODIFIÉS DE LIGANDS DE NKG2D, ET LIGANDS NON NATURELS DE NKG2D QUI SE LIENT À DES RÉCEPTEURS NKG2D NON NATURELS
Abstract
(EN)
This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified α1-α2 domains of NKG2D ligands
(FR)
La présente invention concerne de manière générale la production de polypeptides ayant des propriétés de liaison de l'antigène spécifiques de domaines Fv, par exemple, des fragments variables insérables d'anticorps et des domaines α1-α2 modifiés de ligands de NKG2D.
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