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1. (WO2017023904) NICOTINE-DEGRADING ENZYMES FOR TREATING NICOTINE ADDICTION AND NICOTINE POISONING
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/023904 International Application No.: PCT/US2016/045109
Publication Date: 09.02.2017 International Filing Date: 02.08.2016
IPC:
A61K 31/4439 (2006.01) ,A61K 31/435 (2006.01) ,A61K 35/74 (2015.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
74
Bacteria
Applicants:
THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road La Jolla, California 92037, US
ANTIDOTE THERAPEUTICS, INC. [US/US]; 708 Quince Orchard Rd. Suite 250-C Gaithersburg, MD 20878, US
Inventors:
JANDA, Kim D.; US
KALNIK, Matt; US
THISTED, Thomas; US
Agent:
BRINCKERHOFF, Courtenay; US
AGARWAL, Pavan K.; US
BECK, George; US
BERKOWITZ, Benjamin A.; US
FELDHAUS, John J.; US
HENSCHEL, Rouget; US
KAMINSKI, Michael D.; US
LAW, Glenn; US
MAEBIUS, Stephen B.; US
QUILLIN, George E.; US
RAWLINS, Andrew E.; US
SCHORR, Kristel; US
SIMKIN, Michele M.; US
WEGNER, Harold C.; US
Priority Data:
62/200,96804.08.2015US
Title (EN) NICOTINE-DEGRADING ENZYMES FOR TREATING NICOTINE ADDICTION AND NICOTINE POISONING
(FR) ENZYMES DE DÉGRADATION DE LA NICOTINE POUR LE TRAITEMENT D'UNE DÉPENDANCE À LA NICOTINE ET D'UN EMPOISONNEMENT À LA NICOTINE
Abstract:
(EN) Described herein are methods and compositions for treating nicotine addiction, promoting smoking cessation, reducing the risk of relapse of nicotine consumption, and/or treating nicotine poisoning in a subject in need thereof, using a nicotine-degrading enzyme or an expression vector capable of expressing a nicotine-degrading enzyme in vivo.
(FR) La présente invention concerne des méthodes et des compositions permettant de traiter une dépendance à la nicotine, de favoriser une désaccoutumance du tabac, de réduire le risque de rechute de consommation de nicotine, et/ou de traiter un empoisonnement à la nicotine chez un sujet qui en a besoin, à l'aide d'une enzyme de dégradation de la nicotine ou d'un vecteur d'expression susceptible d'exprimer une enzyme de dégradation de la nicotine in vivo.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)