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1. (WO2017023904) NICOTINE-DEGRADING ENZYMES FOR TREATING NICOTINE ADDICTION AND NICOTINE POISONING

Pub. No.:    WO/2017/023904    International Application No.:    PCT/US2016/045109
Publication Date: Fri Feb 10 00:59:59 CET 2017 International Filing Date: Wed Aug 03 01:59:59 CEST 2016
IPC: A61K 31/4439
A61K 31/435
A61K 35/74
Applicants: THE SCRIPPS RESEARCH INSTITUTE
ANTIDOTE THERAPEUTICS, INC.
Inventors: JANDA, Kim D.
KALNIK, Matt
THISTED, Thomas
Title: NICOTINE-DEGRADING ENZYMES FOR TREATING NICOTINE ADDICTION AND NICOTINE POISONING
Abstract:
Described herein are methods and compositions for treating nicotine addiction, promoting smoking cessation, reducing the risk of relapse of nicotine consumption, and/or treating nicotine poisoning in a subject in need thereof, using a nicotine-degrading enzyme or an expression vector capable of expressing a nicotine-degrading enzyme in vivo.