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1. (WO2017022559) ENVIRONMENT-RESPONSIVE DYE-ACCUMULATED NANO PARTICLES, AND METHOD FOR ANALYZING INTRACELLULAR ENVIRONMENT

Pub. No.:    WO/2017/022559    International Application No.:    PCT/JP2016/071812
Publication Date: Fri Feb 10 00:59:59 CET 2017 International Filing Date: Wed Jul 27 01:59:59 CEST 2016
IPC: G01N 33/52
G01N 33/48
G01N 33/84
Applicants: KONICA MINOLTA, INC.
コニカミノルタ株式会社
Inventors: AIMIYA, Takuji
相宮 拓司
FURUSAWA, Naoko
古澤 直子
Title: ENVIRONMENT-RESPONSIVE DYE-ACCUMULATED NANO PARTICLES, AND METHOD FOR ANALYZING INTRACELLULAR ENVIRONMENT
Abstract:
The present invention addresses the problem of providing environment-responsive dye-accumulated nano particles which can be used for identifying intracellular environments, such as pH values, of individual cells. The present invention provides environment-responsive dye-accumulated nano particles, each of which comprises an environment-responsive dye accumulated on the surface of a heat-curable resin particle or in the inside of the heat-curable resin particle, and which have an average particle diameter of 30 to 800 nm. The nano particles are characterized in that the amount of the accumulated environment-responsive dye is 200 to 10,000,000 molecules/particle. The environment-responsive dye has fluorescence intensity dependency on pH or a Ca ion, and the heat-curable resin is a melamine resin.