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1. WO2017021560 - USE OF HYDROXYCARBAMIDE FOR PREVENTING RETINAL NONPERFUSION

Publication Number WO/2017/021560
Publication Date 09.02.2017
International Application No. PCT/EP2016/068908
International Filing Date 08.08.2016
IPC
A61K 31/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
A61P 27/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
CPC
A61K 31/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 9/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Applicants
  • CENTRE HOSPITALIER NATIONAL D'OPHTALMOLOGIE QUINZE-VINGTS [FR]/[FR]
  • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR]/[FR]
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR]/[FR]
  • IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES [FR]/[FR]
  • ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS [FR]/[FR]
  • UNIVERSITE PARIS DESCARTES [FR]/[FR]
Inventors
  • COLIN, Yves
  • GIRMENS, Jean-François
  • HERMINE, Olivier
  • HERON, Emmanuel
  • PAQUES, Michel
Agents
  • REGIMBEAU
Priority Data
15306277.306.08.2015EP
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) USE OF HYDROXYCARBAMIDE FOR PREVENTING RETINAL NONPERFUSION
(FR) UTILISATION D'HYDROXYCARBAMIDE POUR PREVENIR LA NON-PERFUSION RETINIENNE
Abstract
(EN)
The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.
(FR)
La présente invention concerne l'utilisation de l'Hydroxycarbamide (HC) pour atténuer et/ou retarder l'extension de la non-perfusion capillaire, cause de baisse visuelle irrémédiable chez les patients souffrant d'occlusion de veine centrale de la rétine (OVCR). Il s'agit ici du premier traitement systémique permettant de réduire les complications ischémiques rétiniennes chez des patients dont l'OVCR a été diagnostiquée récemment et est par conséquent dans une phase de progression rapide. Compte tenu de la faible toxicité de l'HC évaluée à grande échelle chez l'enfant et l'adulte dans le cadre d'autres maladies depuis des décennies, les résultats de la présente étude ouvrent une nouvelle voie thérapeutique dans le traitement de l'OVCR.
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