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1. WO2017021424 - GAS PHASE FLUORESCENCE ANALYSIS

Publication Number WO/2017/021424
Publication Date 09.02.2017
International Application No. PCT/EP2016/068471
International Filing Date 02.08.2016
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 5/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
08Measuring devices for evaluating the respiratory organs
G01N 33/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
G01N 21/31 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
CPC
A61B 5/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0071by measuring fluorescence emission
A61B 5/0075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0075by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
A61B 5/082
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
08Detecting, measuring or recording devices for evaluating the respiratory organs
082Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
A61B 5/097
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
08Detecting, measuring or recording devices for evaluating the respiratory organs
097Devices for facilitating collection of breath or for directing breath into or through measuring devices
G01J 3/4406
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
44Raman spectrometry; Scattering spectrometry ; ; Fluorescence spectrometry
4406Fluorescence spectrometry
G01N 2021/391
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
39using tunable lasers
391Intracavity sample
Applicants
  • UNIVERSITY OF DURHAM [GB]/[GB]
Inventors
  • CARTY, David
  • WREDE, Eckart
  • NAHLER, Nils Hendrik
Agents
  • BROWNE, Robin Forsythe
Priority Data
1513700.303.08.2015GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GAS PHASE FLUORESCENCE ANALYSIS
(FR) ANALYSE PAR FLUORESCENCE EN PHASE GAZEUSE
Abstract
(EN)
A method and apparatus for quantifying an analyte in a gas phase or liquid sample comprises: a pulsed or continuous, coherent or incoherent light source (10), a pair of reflective mirrors (13) located on the optical axis forming an optical cavity, and a cell (4) located between the mirrors (13), the cell (4) having a gas inlet (3) and a gas outlet (5); a fluorescence detector (17) located off the cavity axis and arranged to provide a first signal in response to fluorescence within the cavity; a photon detector (14) located axially external to the cavity and arranged to provide a second signal; wherein the apparatus including the axial photon detector (14) is configured to comprise a cavity enhanced absorption spectrometer; wherein apparatus including the off-axis photon detector is configured to comprise a cavity-enhanced laser-induced fluorescence (CELIF) spectrophotometer; means for supplying a pure sample or an analyte-containing sample to the cavity; a processor (9) adapted to receive a first signal to calibrate the apparatus and to receive a second signal to provide a measurement of the concentration of the analyte in the sample.
(FR)
La présente invention concerne un procédé et un appareil pour quantifier un analyte dans un échantillon en phase gazeuse ou liquide qui comprend : une source de lumière pulsée ou continue, cohérente ou incohérente (10), une paire de miroirs réfléchissants (13) situés sur l'axe optique formant une cavité optique, et une cellule (4) située entre les miroirs (13), la cellule (4) ayant une entrée de gaz (3) et une sortie de gaz (5) ; un détecteur de fluorescence (17) situé hors de l'axe de cavité et agencé pour fournir un premier signal en réponse à la fluorescence à l'intérieur de la cavité ; un détecteur de photon (14) axialement situé à l'extérieur de la cavité et agencé pour fournir un deuxième signal ; l'appareil comprenant le détecteur de photon axial (14) étant configuré de manière à comprendre un spectromètre d'absorption à cavité ; l’appareil comprenant le détecteur de photon désaxé étant configuré de manière à comprendre un spectrophotomètre de fluorescence induite par laser à cavité (CELIF) ; des moyens pour disposé un échantillon pur ou un échantillon contenant un analyte dans la cavité ; un processeur (9) adapté pour recevoir un premier signal pour étalonner l'appareil et pour recevoir un deuxième signal pour fournir une mesure de la concentration de l'analyte dans l'échantillon.
Also published as
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