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1. (WO2017021362) ANTIBODY CONSTRUCTS FOR FLT3 AND CD3

Pub. No.:    WO/2017/021362    International Application No.:    PCT/EP2016/068319
Publication Date: Fri Feb 10 00:59:59 CET 2017 International Filing Date: Tue Aug 02 01:59:59 CEST 2016
IPC: C07K 16/28
C07K 16/46
Applicants: AMGEN RESEARCH (MUNICH) GMBH
Inventors: RAUM, Tobias
PENDZIALEK, Jochen
BLUEMEL, Claudia
BOTT, Franziska
DAHLHOFF, Christoph
HOFFMANN, Patrick
NAHRWOLD, Elisabeth
Title: ANTIBODY CONSTRUCTS FOR FLT3 AND CD3
Abstract:
The present disclosure relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the disclosure provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the disclosure provides a process for the production of the antibody construct of the disclosure, a medical use of said antibody construct and a kit comprising said antibody construct.