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1. (WO2017021356) BISPECIFIC ANTIBODY CONSTRUCTS BINDING MESOTHELIN AND CD3
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/021356 International Application No.: PCT/EP2016/068304
Publication Date: 09.02.2017 International Filing Date: 01.08.2016
Chapter 2 Demand Filed: 31.05.2017
IPC:
C07K 16/28 (2006.01) ,C07K 16/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
Applicants: AMGEN RESEARCH (MUNICH) GMBH[DE/DE]; Staffelseestrasse 2 81477 Munich, DE
AMGEN INC.[US/US]; One Amgen Center Drive Thousand Oaks, California 91320-1799, US
Inventors: RAUM, Tobias; DE
KUFER, Peter; DE
RAU, Doris; DE
ANLAHR, Jonas; DE
BLUEMEL, Claudia; DE
HOFFMANN, Patrick; DE
NAHRWOLD, Elisabeth; DE
BAILIS, Julie; US
Agent: WEINZIERL, Gerhard; DE
KOCH, Andreas; DE
SCHIWECK, Wolfram; DE
Priority Data:
62/199,93931.07.2015US
62/290,86103.02.2016US
Title (EN) BISPECIFIC ANTIBODY CONSTRUCTS BINDING MESOTHELIN AND CD3
(FR) CONSTRUCTIONS D'ANTICORPS BISPÉCIFIQUES SE LIANT À LA MÉSOTHÉLINE ET À CD3
Abstract:
(EN) The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
(FR) La présente invention concerne une construction d'anticorps bispécifique comprenant un premier domaine de liaison qui se lie à la MSLN humaine sur la surface d'une cellule cible et un second domaine de liaison qui se lie au CD3 humain sur la surface d'un lymphocyte T. De plus, l'invention concerne un polynucléotide codant pour la construction d'anticorps, un vecteur comprenant ledit polynucléotide et une cellule hôte transformée ou transfectée avec ledit polynucléotide ou vecteur. Un procédé de production de la construction d'anticorps selon l'invention, un usage médical de ladite construction d'anticorps et un kit la comprenant sont en outre décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)