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1. (WO2017020291) NOVEL ANTI-PD-L1 ANTIBODIES

Pub. No.:    WO/2017/020291    International Application No.:    PCT/CN2015/086216
Publication Date: Fri Feb 10 00:59:59 CET 2017 International Filing Date: Fri Aug 07 01:59:59 CEST 2015
IPC: C07K 16/28
C12N 15/13
C12N 15/63
C12N 5/10
A61K 39/395
A61P 35/00
Applicants: WUXI BIOLOGICS (SHANGHAI) CO. LTD.
OPEN MONOCLONAL TECHNOLOGY, INC.
Inventors: ZHENG, Yong
LI, Jing
CHEN, Zhisheng
Title: NOVEL ANTI-PD-L1 ANTIBODIES
Abstract:
The present disclosure provides monoclonal antibodies against protein programmed cell death 1 ligand (PD-L1), which can block the binding of PD-L1 to PD-1, and therefore block the inhibitory function of PD-L1 on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.