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1. (WO2017019918) TARGETED OLIGONUCLEOTIDES

Pub. No.:    WO/2017/019918    International Application No.:    PCT/US2016/044595
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Fri Jul 29 01:59:59 CEST 2016
IPC: C07H 19/173
C07H 21/00
C07H 19/19
C07H 19/09
Applicants: CARIS SCIENCE, INC.
Inventors: O'NEILL, Heather
MAYER, Gunter
MIGLARESE, Mark
SPETZLER, David
Title: TARGETED OLIGONUCLEOTIDES
Abstract:
Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.