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1. (WO2017019905) TREATMENT USING TRUNCATED TRK B AND TRK C ANTAGONISTS
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Pub. No.: WO/2017/019905 International Application No.: PCT/US2016/044570
Publication Date: 02.02.2017 International Filing Date: 28.07.2016
IPC:
A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
SARAGOVI, Horacio Uri [US/CA]; CA
OTONOMY, INC. [US/US]; 4796 Executive Drive San Diego, California 92121, US
Inventors:
SARAGOVI, Horacio Uri; CA
PIU, Fabrice; US
Agent:
YANG, Xiaofan; US
Priority Data:
62/198,06228.07.2015US
Title (EN) TREATMENT USING TRUNCATED TRK B AND TRK C ANTAGONISTS
(FR) TRAITEMENT UTILISANT DES ANTAGONISTES DE TRK B ET TRK C TRONQUÉS
Abstract:
(EN) Disclosed herein are methods, compositions, vectors, and kits comprising an antagonist of a truncated TrkC or a truncated TrkB. Also described herein are methods of treating and/or preventing an otic disease or condition associated with an elevated expression level of a truncated TrkC or truncated TrkB isoform.
(FR) L'invention concerne des méthodes, des compositions, des vecteurs et des kits comprenant un antagoniste d'un TrkC tronqué ou d'un TrkB tronqué. L'invention concerne également des méthodes de traitement et/ou de prévention d'une maladie ou d'une affection otique associée à un niveau d'expression élevé d'une isoforme de TrKC tronqué ou de TrkB tronqué.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)