Search International and National Patent Collections

1. (WO2017019778) LUNG DISEASE MODELS ON A CHIP

Pub. No.:    WO/2017/019778    International Application No.:    PCT/US2016/044282
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Thu Jul 28 01:59:59 CEST 2016
IPC: B01L 99/00
B81B 1/00
C12M 3/00
C12N 5/00
G01N 33/50
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors: HUH, Dongeun
MONDRINOS, Mark
BYUN, Woo Yul
Title: LUNG DISEASE MODELS ON A CHIP
Abstract:
The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.