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1. (WO2017019767) Inhibition of CXCL12 in Cancer Immunotherapy
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Pub. No.: WO/2017/019767 International Application No.: PCT/US2016/044254
Publication Date: 02.02.2017 International Filing Date: 27.07.2016
C07K 16/24 (2006.01)
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
against material from animals or humans
against cytokines, lymphokines or interferons
Applicants: MYOSOTIS, LLC[US/US]; 155 Lambert Drive Princeton, New Jersey 08540, US
Inventors: FEARON, Douglas; US
Agent: WALES, Michele M.; US
Priority Data:
Title (EN) Inhibition of CXCL12 in Cancer Immunotherapy
(EN) A method is described for increasing effector T-cell accumulation in cancer cell-containing sites of a tumor, comprising administering to a subject in need thereof a pharmaceutically effective amount of a CXCL12-targeted immune response agent. In some embodiments, the CXCL12-targeted immune response agent is administered with another molecule that inhibits or destroys the tumor cell.
(FR) L'invention concerne un procédé permettant d'augmenter l'accumulation de lymphocytes T effecteurs dans des sites contenant des cellules cancéreuses d'une tumeur, consistant à administrer à un sujet qui en a besoin une quantité pharmaceutiquement efficace d'un agent de réponse immunitaire ciblant CXCL12. Dans certains modes de réalisation, l'agent de réponse immunitaire ciblant CXCL12 est administré avec une autre molécule qui inhibe ou détruit la cellule tumorale.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)