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1. (WO2017019616) BILE ACID RECEPTOR AGONISM FOR TREATING ADDICTION

Pub. No.:    WO/2017/019616    International Application No.:    PCT/US2016/043891
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Tue Jul 26 01:59:59 CEST 2016
IPC: A61K 31/00
A61K 31/575
A61P 25/30
Applicants: VANDERBILT UNIVERSITY
Inventors: GALLI, Aurelio
REDDY, India A.
ABUMRAD, Naji N.
ERREGER, Kevin
MATTHIES, Heinrich J.
FLYNN, Charles Robb
Title: BILE ACID RECEPTOR AGONISM FOR TREATING ADDICTION
Abstract:
Compositions and methods for treating addiction in a subject are disclosed. In particular, compositions and methods for treating addiction to a dopaminergic psychostimulant are disclosed. In some embodiments, addiction is treated by agonizing bile acid receptors in the subject. For example, in some embodiments, the method comprises administering to the subject a therapeutically effective amount of a composition comprising a therapeutically effective amount of a bile acid receptor agonist. In some embodiments, the method comprises surgically diverting bile acids in the subject in a manner suitable to increase circulating bile acids in the subject.