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1. (WO2017019542) RADIAL MICROFLUIDIC DEVICES AND METHODS OF USE

Pub. No.:    WO/2017/019542    International Application No.:    PCT/US2016/043674
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Sat Jul 23 01:59:59 CEST 2016
IPC: A61K 35/12
A61K 35/51
B01L 3/00
C12M 1/26
C12N 5/073
G01N 33/50
G05D 7/01
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors: NOVAK, Richard
CONEGLIANO, David
TEIXEIRA, Liliana
INGBER, Donald, E.
Title: RADIAL MICROFLUIDIC DEVICES AND METHODS OF USE
Abstract:
A microfluidic device for simulating a function or response of a tissue is disclosed. The device includes an inlet for receiving a fluid in the device, and an outlet for removing the fluid from the device. The device further includes a fluid channel in fluid communication with the inlet and the outlet for flowing the fluid through the device. The fluid channel defines a chamber well that receives cells associated with the tissue. The device also includes an interface structure between the fluid channel and the chamber well for permitting migration of at least one of cells, particulates, chemicals, molecules, liquids, or gases between the fluid within the fluid channel and the chamber well.