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1. (WO2017019533) MULTI-EPITOPE HSV UL39 VACCINE AND METHODS FOR USING SAME

Pub. No.:    WO/2017/019533    International Application No.:    PCT/US2016/043645
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Sat Jul 23 01:59:59 CEST 2016
IPC: A61K 39/42
A61K 35/763
A61K 39/12
A61K 39/245
C07K 14/035
C12N 15/38
C12N 15/63
Applicants: UNIVERSITY OF WASHINGTON
ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (ERASMUS MC)
Inventors: KOELLE, David M.
JING, Lichen
JOHNSTON, Christine
WALD, Anna
VERJANS, George M.G.M.
Title: MULTI-EPITOPE HSV UL39 VACCINE AND METHODS FOR USING SAME
Abstract:
The invention provides multiple epitopes of HSV UL39 that are cross-reactive and are useful for the prevention and treatment of alphaherpesvirus infection across a broad spectrum of the population. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing epitopes or polynucleotides encoding epitopes of the invention provide effectively targeted vaccines for prevention and treatment of alphaherpesvirus infection.