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|1. (WO2017019533) MULTI-EPITOPE HSV UL39 VACCINE AND METHODS FOR USING SAME|
|Applicants:||UNIVERSITY OF WASHINGTON
ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (ERASMUS MC)
|Inventors:||KOELLE, David M.
VERJANS, George M.G.M.
|Title:||MULTI-EPITOPE HSV UL39 VACCINE AND METHODS FOR USING SAME|
The invention provides multiple epitopes of HSV UL39 that are cross-reactive and are useful for the prevention and treatment of alphaherpesvirus infection across a broad spectrum of the population. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing epitopes or polynucleotides encoding epitopes of the invention provide effectively targeted vaccines for prevention and treatment of alphaherpesvirus infection.