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1. (WO2017019174) METHOD OF PRODUCING BIVALIRUDIN

Pub. No.:    WO/2017/019174    International Application No.:    PCT/US2016/034985
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Wed Jun 01 01:59:59 CEST 2016
IPC: C07K 1/04
C07K 1/06
C07K 14/815
Applicants: AMBIOPHARM, INC.
Inventors: ZHANG, Guoqing
ZHANG, Ruoping
BAI, Juncai
Title: METHOD OF PRODUCING BIVALIRUDIN
Abstract:
The present disclosure provides a method of producing bivalirudin using a peptide fragment or peptide fragments on solid phase peptide synthesis that minimizes, or eliminates, the production of bivalirudin molecules having too few or too many glycine residues.