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1. (WO2017019059) SYSTEMS AND METHODS FOR AUTOMATED SEGMENTATION OF INDIVIDUAL SKELETAL BONES IN 3D ANATOMICAL IMAGES

Pub. No.:    WO/2017/019059    International Application No.:    PCT/US2015/042631
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Thu Jul 30 01:59:59 CEST 2015
IPC: G06T 7/00
G06K 9/34
Applicants: PERKINELMER HEALTH SCIENCES, INC.
PERKINELMER CELLULAR TECHNOLOGIES GERMANY GMBH
Inventors: BEHROOZ, Ali
KASK, Peet
Title: SYSTEMS AND METHODS FOR AUTOMATED SEGMENTATION OF INDIVIDUAL SKELETAL BONES IN 3D ANATOMICAL IMAGES
Abstract:
Presented herein, in certain embodiments, are approaches for robust bone splitting and segmentation in the context of small animal imaging, for example, microCT imaging. In certain embodiments, a method for calculating and applying single and hybrid second-derivative splitting filters to gray-scale images and binary bone masks is described. These filters can accurately identify the split lines/planes of the bones even for low-resolution data, and hence accurately morphologically disconnect the individual bones. The split bones can then be used as seeds in region growing techniques such as marker-controlled watershed segmentation. With this approach, the bones can be segmented with much higher robustness and accuracy compared to prior art methods.