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1. WO2017018060 - PRODUCTION METHOD FOR CYSTEINE DERIVATIVE AND CYSTEINE SULFOXIDE DERIVATIVE

Publication Number WO/2017/018060
Publication Date 02.02.2017
International Application No. PCT/JP2016/066974
International Filing Date 07.06.2016
IPC
C12P 13/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta-amino acids
12Methionine; Cysteine; Cystine
C12N 9/88 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88Lyases (4.)
C12N 15/09 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
CPC
C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
C12N 9/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
88Lyases (4.)
C12P 13/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta- amino acids
12Methionine; Cysteine; Cystine
Applicants
  • 味の素株式会社 AJINOMOTO CO., INC. [JP]/[JP]
Inventors
  • 山本 英樹 YAMAMOTO, Hideki
  • 菅原 誠吾 SUGAWARA, Seigo
Agents
  • 高島 一 TAKASHIMA, Hajime
Priority Data
2015-14793627.07.2015JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PRODUCTION METHOD FOR CYSTEINE DERIVATIVE AND CYSTEINE SULFOXIDE DERIVATIVE
(FR) PROCÉDÉ DE PRODUCTION D'UN DÉRIVÉ DE CYSTÉINE ET D'UN DÉRIVÉ DE CYSTÉINE SULFOXYDE
(JA) システイン誘導体及びシステインスルホキシド誘導体の製造方法
Abstract
(EN)
The present invention provides a method for reacting a thiol compound represented by formula (I) (R in the formula is as defined in the description) with L-serine in the presence of cystathionine β-synthase to produce a cysteine derivative represented by formula (II) (R in the formula is as defined above), and a method for reacting the cysteine derivative with an oxidase and a substrate thereof to produce a cysteine sulfoxide derivative represented by formula (III) (R in the formula is as defined above). With these methods, it is possible to produce the cysteine derivative and the cysteine sulfoxide derivative stably on an industrial scale and using means that are safe for use in food products.
(FR)
La présente invention concerne un procédé de réaction d'un composé de thiol représenté par la formule (I) (R dans la formule est tel que défini dans la description) avec une L-sérine en présence d'une cystathionine β-synthase pour obtenir un dérivé de cystéine représenté par la formule (II) (R dans la formule est tel que défini ci-dessus), et un procédé de réaction du dérivé de cystéine avec une oxydase et un substrat pour celle-ci pour obtenir un dérivé de cystéine sulfoxyde représenté par la formule (III) (R dans la formule est tel que défini ci-dessus). Ces procédés permettent d'obtenir le dérivé de cystéine et le dérivé de cystéine sulfoxyde de manière stable à l'échelle industrielle et en utilisant des moyens qui sont sans danger pour une utilisation dans des produits alimentaires.
(JA)
本願発明は、シスタチオニンβ-シンターゼの存在下、式(I): (式中、Rは明細書中に記載の通りである) で表されるチオール化合物とL-セリンとを反応させて式(II): (式中、Rは上述の通りである) で表されるシステイン誘導体を製造する方法、及び 該システイン誘導体と、オキシダーゼ及びその基質とを反応させて式(III): (式中、Rは上述の通りである) で表されるシステインスルホキシド誘導体を製造する方法を提供する。当該方法により、システイン誘導体やシステインスルホキシド誘導体を、工業的規模で安定的に、且つ食品に使用する際にも安全な方法で製造することが可能となる。
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