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1. (WO2017017571) TREATMENT FOR VITILIGO
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/017571 International Application No.: PCT/IB2016/054355
Publication Date: 02.02.2017 International Filing Date: 21.07.2016
IPC:
A61K 31/00 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 31/472 (2006.01) ,A61K 31/4725 (2006.01) ,A61K 31/55 (2006.01) ,A61P 17/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
472
Non-condensed isoquinolines, e.g. papaverine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
472
Non-condensed isoquinolines, e.g. papaverine
4725
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
Applicants: GLAXO GROUP LIMITED[GB/GB]; 980 Great West Road Brentford Middlesex TW89GS, GB
Inventors: DICKSON, Marion Catherine; GB
RUBENSTEIN, David; US
Priority Data:
62/196,34924.07.2015US
Title (EN) TREATMENT FOR VITILIGO
(FR) TRAITEMENT DU VITILIGO
Abstract:
(EN) A method of treating vitiligo, including prophylaxis, in a subject in need thereof, comprising administering to said subject a pharmaceutically effective amount of a compound of Formula (I): (I) wherein: X is CR1 or N; Y is CH, C or N; R1 is hydrogen, C1-6alkoxy or C1-6alkyl; R2 is hydrogen, C1-6alkoxy, halo, -C(O)C1-6alkyl, CN, halo-C1-6alkyl or -C(O)NR4R5; R3 is hydrogen or C1-6alkoxy; R4 is hydrogen or C1-6alkyl: R5 is hydrogen or C1-6alkyl; and m and n are integers each independently selected from 1 and 2, or a pharmaceutically acceptable salt thereof.
(FR) L’invention concerne une méthode de traitement, y compris de prophylaxie, du vitiligo chez un sujet qui en a besoin, la méthode consistant à administrer audit sujet une quantité suffisante d’un composé de la formule (I) ou un sel pharmaceutiquement acceptable dudit composé. Dans la formule (I) : X désigne CR1 ou N ; R1 désigne un atome d’hydrogène, un groupe alkoxy C1-6 ou alkyle C1-6 ; R2 désigne un atome d’hydrogène, un groupe alkoxy C1-6, haloalkyle C(O)C1-6, CN, haloalkyle C1-6 ou C(O)NR4R5 ; R3 désigne un atome d’hydrogène ou un groupe alkoxy C1-6 ; R4 désigne un atome d’hydrogène ou un groupe alkyle C1-6 ; R5 désigne un atome d’hydrogène ou un groupe alkyle C1-6 ; et m et n sont des entiers choisis indépendamment l’un de l’autre entre 1 et 2.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)