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1. (WO2017017423) NASAL SAMPLING METHODS

Pub. No.:    WO/2017/017423    International Application No.:    PCT/GB2016/052249
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Sat Jul 23 01:59:59 CEST 2016
IPC: A61B 10/00
C12N 5/079
Applicants: GENOME RESEARCH LIMITED
Inventors: LOGAN, Darren
GURRIA, Gabriela
GANE, Simon
Title: NASAL SAMPLING METHODS
Abstract:
This invention relates to a non-invasive method for obtaining samples of olfactory epithelium (OE) cells, such as olfactory sensory neurons (OSNs), from patients. The method comprises directing a jet of sampling solution into a nostril of an individual, recovering the sampling solution from a nostril of the individual, and isolating olfactory epithelium cells from the recovered sampling solution. Samples obtained by this method may be useful in for a range of research and diagnostic applications, including the diagnosis and prognosis of diseases such as CNS disorders, neurodegenerative disease, psychiatric diseases or cancer.