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1. (WO2017017184) MODIFIED NATURAL KILLER CELLS AND NATURAL KILLER CELL LINES HAVING INCREASED CYTOTOXICITY

Pub. No.:    WO/2017/017184    International Application No.:    PCT/EP2016/068001
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Fri Jul 29 01:59:59 CEST 2016
IPC: C12N 5/0783
A61K 35/17
C12N 15/63
Applicants: ONKIMMUNE LIMITED
Inventors: O'DWYER, Michael Eamon Peter
Title: MODIFIED NATURAL KILLER CELLS AND NATURAL KILLER CELL LINES HAVING INCREASED CYTOTOXICITY
Abstract:
NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) TRAIL ligand expression.