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1. (WO2017017026) NEW POLYPEPTIDE HAVING FERREDOXIN-NADP+ REDUCTASE ACTIVITY, POLYNUCLEOTIDE ENCODING THE SAME AND USES THEREOF

Pub. No.:    WO/2017/017026    International Application No.:    PCT/EP2016/067568
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Sat Jul 23 01:59:59 CEST 2016
IPC: C12N 9/02
C12P 7/06
C12P 7/16
C12P 7/18
Applicants: INSTITUT NATIONAL DES SCIENCES APPLIQUEES
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Inventors: SOUCAILLE, Philippe
MEYNIAL-SALLES, Isabelle
FOULQUIER, Céline
RIVIERE, Antoine
Title: NEW POLYPEPTIDE HAVING FERREDOXIN-NADP+ REDUCTASE ACTIVITY, POLYNUCLEOTIDE ENCODING THE SAME AND USES THEREOF
Abstract:
The present invention relates to a novel polypeptide having the enzymatic activity of reduction of NADP+ using electrons from reduced ferredoxin (Ferredoxin-NADP+ reductase activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof. The invention relates to the modulation of the Ferredoxin NADP+ reductase activity in a microorganism by varying the expression level of the polynucleotide coding for such polypeptide. The invention also relates to the production of commodity chemicals, especially ethanol, n- butanol, 1,3-propanediol, 1,2-propanediol, isopropanol and acetone by fermenting microorganisms wherein their Ferredoxin NADP+ reductase activity is modulated.