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1. (WO2017015750) FLUIDIC SYSTEMS, DEVICES AND METHODS FOR INDUCING ANISOTROPY IN POLYMERIC MATERIALS

Pub. No.:    WO/2017/015750    International Application No.:    PCT/CA2016/050869
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Sat Jul 23 01:59:59 CEST 2016
IPC: C08J 5/18
A61L 27/38
A61L 27/40
B29C 47/00
C12M 3/04
C12N 5/077
Applicants: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
BETH ISRAEL DEACONESS MEDICAL CENTRE, INC.
Inventors: LENG, Lian
GRAINGER, Stephanie
CHAIKOF, Elliot L.
GUENTHER, Axel
MIRANDA NIEVES, David
MALLADI, Shashi
CHENG, Richard
Title: FLUIDIC SYSTEMS, DEVICES AND METHODS FOR INDUCING ANISOTROPY IN POLYMERIC MATERIALS
Abstract:
Systems, devices and methods are provided for fabricating anisotropic polymer materials. According to various embodiments, a fluidic device is employed to distribute a polymer solution and a flow-confining solution in order to generate a layered flow, where the layered flow is formed such that a polymer liquid sheet is sheathed on opposing sides by flow-confining liquid sheets. The fluidic device includes first and second fluid conduits, where the first fluid conduit receives the layered flow. The second fluid conduit has a reduced height relative to the first fluid conduit, such that the layered flow is constricted as it flows through the second fluid conduit. The constriction formed by the second flow conduit causes hydrodynamic focusing, reducing the thickness of the polymer liquid sheet, and inducing molecular alignment and anisotropy within the polymer liquid sheet as it is hardened and as strain is applied during extrusion of the sheet.