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1. (WO2017015720) FIBROTIC TREATMENT

Pub. No.:    WO/2017/015720    International Application No.:    PCT/AU2016/050681
Publication Date: Fri Feb 03 00:59:59 CET 2017 International Filing Date: Sat Jul 30 01:59:59 CEST 2016
IPC: A61K 31/4433
A61K 31/4709
A61K 31/351
A61K 38/08
A61P 11/00
A61P 19/04
A61P 9/00
A61P 17/02
A61P 1/16
A61P 13/12
Applicants: MONASH UNIVERSITY
Inventors: CHAI, Siew Yeen
WIDDOP, Robert
GASPARI, Tracey
LEE, Huey Wen
Title: FIBROTIC TREATMENT
Abstract:
The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group including HFI- 419, HA-08, AL-40, HFI-437, Val-Tyr-Ile-His-Pro-Phe (otherwise known as angiotensin IV or ANG IV), c[Cys-Tyr-Cys]-His-Pro- Phe, and c[Hcy-Tyr-Hcy]-His-Pro-Phe.