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1. WO2017006349 - POLYSACCHARIDE VACCINE FORMULATIONS AND PROCESSES FOR INDUSTRIAL PRODUCTION OF BACTERIAL POLYSACCHARIDES

Publication Number WO/2017/006349
Publication Date 12.01.2017
International Application No. PCT/IN2016/050218
International Filing Date 04.07.2016
IPC
A61K 39/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
A61K 39/095 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
095Neisseria
A61K 39/112 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
112Salmonella; Shigella
CPC
A61K 2039/6037
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
A61K 2039/6087
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6087Polysaccharides; Lipopolysaccharides [LPS]
A61K 2039/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
70Multivalent vaccine
A61K 39/0275
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
025Enterobacteriales, e.g. Enterobacter
0275Salmonella
A61K 39/095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
095Neisseria
A61K 39/116
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
116Polyvalent bacterial antigens
Applicants
  • BHARAT BIOTECH INTERNATIONAL LIMITED [IN]/[IN]
Inventors
  • ELLA, Krishna Murthy
  • KUMAR, Ashawani
  • RAMASWAMY, Venkatesan
  • MURTHY, Voleti Subrahmanya Ramachandra
Agents
  • HASAN, Afzal
  • HASAN, Vatsala Singh
Priority Data
3426/CHE/201504.07.2015IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) POLYSACCHARIDE VACCINE FORMULATIONS AND PROCESSES FOR INDUSTRIAL PRODUCTION OF BACTERIAL POLYSACCHARIDES
(FR) FORMULATIONS VACCINALES À BASE DE POLYSACCHARIDES ET PROCÉDÉS DE PRODUCTION INDUSTRIELLE DE POLYSACCHARIDES BACTÉRIENS
Abstract
(EN) The present invention relates to the field of combined vaccine compositions which are effective against all forms of meningococcal diseases as well as typhoid fever. The vaccine formulations comprising antigens from capsular polysaccharides of Neisseria meningitidis A, Neisseria meningitidis C, Neisseria meningitidis Y, Neisseria meningitidis W135, Neisseria meningitidis X, Salmonella typhi Vi capsular polysaccharide (ViPs) or capsular ViPs conjugated to a carrier protein tetanus toxoid (ViPs-TT). This invention is also related to improved methods, especially the use of an improved feed media and an improved method of downstream processing and industrial purification of capsular polysaccharides. The vaccine is free of any animal component or alcohol and is in absolute compliance with respect to the religious sentiments of various ethnic groups. The composition is highly effective and stable, yet cost- effective and affordable, especially for lower-middle income and low-income countries.
(FR) La présente invention concerne le domaine des compositions vaccinales combinées qui sont efficaces contre toutes les formes des maladies à méningocoques ainsi que la fièvre typhoïde. Les formulations vaccinales selon l'invention comprennent des antigènes provenant des polysaccharides capsulaires de Neisseria meningitidis A, Neisseria meningitidis C, Neisseria meningitidis Y, Neisseria meningitidis W135, des polysaccharides capsulaires de Neisseria meningitidis X, Salmonella typhi Vi (ViPs) ou des ViPs capsulaires conjugués à une protéine porteuse de l'anatoxine tétanique (ViPs-TT). L'invention concerne également des procédés améliorés, en particulier l'utilisation d'un support alimentaire amélioré et un procédé de transformation aval et de purification industrielle des polysaccharides capsulaires améliorés. Le vaccin est exempt de tout composant d'origine animale ou d'alcool et dans le respect absolu des croyances religieuses des différents groupes ethniques. La composition est extrêmement efficace et stable, tout en restant rentable et abordable, notamment pour les pays à revenus moyens bas et à bas revenus.
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