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1. WO2017005668 - ARYL SULTAM DERIVATIVES AS RORc MODULATORS

Publication Number WO/2017/005668
Publication Date 12.01.2017
International Application No. PCT/EP2016/065643
International Filing Date 04.07.2016
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
279
Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02
1,2-Thiazines; Hydrogenated 1,2-thiazines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
541
Non-condensed thiazines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
C07D 417/10 (2006.01)
C07D 279/02 (2006.01)
A61K 31/541 (2006.01)
A61P 37/00 (2006.01)
A61P 19/02 (2006.01)
CPC
A61K 31/541
A61P 11/06
A61P 17/06
A61P 19/02
A61P 29/00
A61P 37/02
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (US)
Inventors
  • RENE, Olivier; US
  • FAUBER, Benjamin; US
  • VESEY, David; GB
  • WINSHIP, Paul; GB
  • LADDUWAHETTY, Tammy; GB
Agents
  • BERNARD, Guillaume; CH
Priority Data
62/190,15008.07.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ARYL SULTAM DERIVATIVES AS RORc MODULATORS
(FR) DÉRIVÉS D'ARYLE SULTAME UTILISÉS COMME MODULATEURS DE RORC
Abstract
(EN)
Compounds of the formula I: or a pharmaceutical salt thereof, wherein p, s, A, R3 and Re are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
(FR)
L'invention concerne des composés représentés par la formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci. Dans cette formule, p, s, A, R3 et Re sont tels que définis dans la description. L'invention concerne également des procédés pour la fabrication de ces composés et l'utilisation de ces composés pour le traitement de maladies inflammatoires telles que l'arthrite.
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