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1. (WO2017004537) (4-((3R,4R)-3-METHOXYTETRAHYDRO-PYRAN-4-YLAMINO)PIPERIDIN-1-YL)(5-METHYL-6-(((2R,6S)-6-(P-TOLYL)TETRAHYDRO-2H-PYRAN-2-YL)METHYLAMINO)PYRIMIDIN-4YL)METHANONE CITRATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/004537 International Application No.: PCT/US2016/040728
Publication Date: 05.01.2017 International Filing Date: 01.07.2016
IPC:
C07D 405/14 (2006.01) ,A61K 31/506 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
CENTREXION THERAPEUTICS CORPORATION [US/US]; 509 South Exeter Street Suite 202 Baltimore, MD 21202, US
Inventors:
OSTERMEIER, Markus; DE
WERTHMANN, Ulrike; DE
EBEL, Heiner; DE
GIOVANNINI, Riccardo; DE
SCHEURER, Stefan; DE
FRATTINI, Sara; DE
Agent:
DAVIS, Chad, E.; US
Priority Data:
15175066.802.07.2015EP
Title (EN) (4-((3R,4R)-3-METHOXYTETRAHYDRO-PYRAN-4-YLAMINO)PIPERIDIN-1-YL)(5-METHYL-6-(((2R,6S)-6-(P-TOLYL)TETRAHYDRO-2H-PYRAN-2-YL)METHYLAMINO)PYRIMIDIN-4YL)METHANONE CITRATE
(FR) CITRATE DE (4-((3R,4R)-3-MÉTHOXYTÉTRAHYDRO-PYRAN-4-YLAMINO)PIPÉRIDIN-1-YL)(5-MÉTHYL-6-(((2R,6S)-(P-TOLYL)TÉTRAHYDRO-2H-PYRAN-2-YL)MÉTHYLAMINO)PYRIMIDIN-4-YL)MÉTHANONE
Abstract:
(EN) The invention provides a salt of a tetrahydropyranylmethylaminopyrimidine amide, such as the citrate salt of (4-((3R,4R)-3-methoxytetrahydropyran-4-ylamino)piperidin-l-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone, pharmaceutical compositions containing the same, processes for preparing the same, and methods of medical treatment using the same.
(FR) La présente invention concerne un sel d'un tétrahydropyranylméthylaminopyrimidine amide, tel que le sel de citrate de (4-((3-R,4R)-3-méthoxytétrahydropyran-4-ylamino)pipéridin-1-yl)(5-méthyl-6-(((R,6S-6-(p-tolyl)tétrahydro-2H-pyran-2-yl)méthylamino)pyrimidin-4-yl)méthanone, des compositions pharmaceutiques le contenant, des procédés pour sa préparation et des méthodes de traitement médical l'utilisant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2990460AU2016287584IL256530EP3317270IN201847003408US20180207157
CN108026087JP2018524342BR112017028492