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1. (WO2017002853) HETERO TYPE MONODISPERSED POLYETHYLENE GLYCOL, INTERMEDIATE FOR PRODUCTION OF HETERO TYPE MONODISPERSED POLYETHYLENE GLYCOL, METHODS FOR PRODUCING SAME, AND HETERO TYPE MONODISPERSED POLYETHYLENE GLYCOL CONJUGATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/002853 International Application No.: PCT/JP2016/069266
Publication Date: 05.01.2017 International Filing Date: 29.06.2016
IPC:
C08G 65/333 (2006.01) ,C08G 65/334 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
65
Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
02
from cyclic ethers by opening of the heterocyclic ring
32
Polymers modified by chemical after-treatment
329
with organic compounds
333
containing nitrogen
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
65
Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
02
from cyclic ethers by opening of the heterocyclic ring
32
Polymers modified by chemical after-treatment
329
with organic compounds
334
containing sulfur
Applicants:
株式会社東北テクノアーチ TOHOKU TECHNO ARCH CO., LTD. [JP/JP]; 宮城県仙台市青葉区荒巻字青葉468番地 468, Aza Aoba, Aramaki, Aoba-ku, Sendai-shi, Miyagi 9800845, JP
日油株式会社 NOF CORPORATION [JP/JP]; 東京都渋谷区恵比寿四丁目20番3号 20-3, Ebisu 4-chome, Shibuya-ku, Tokyo 1506019, JP
Inventors:
金原 数 KINBARA Kazushi; JP
村岡 貴博 MURAOKA Takahiro; JP
ヴアブロ アダム マルシン WAWRO Adam Marcin; JP
大嶽 知之 OHTAKE Tomoyuki; JP
姜 義哲 KANG Eui-chul; JP
宇留賀 友輝 URUGA Tomoki; JP
今村 龍太郎 IMAMURA Ryutaro; JP
Agent:
特許業務法人 信栄特許事務所 SHIN-EI PATENT FIRM, P.C.; 東京都港区西新橋一丁目7番13号 虎ノ門イーストビルディング8階 Toranomon East Bldg. 8F, 7-13, Nishi-Shimbashi 1-chome, Minato-ku, Tokyo 1050003, JP
Priority Data:
2015-13174430.06.2015JP
Title (EN) HETERO TYPE MONODISPERSED POLYETHYLENE GLYCOL, INTERMEDIATE FOR PRODUCTION OF HETERO TYPE MONODISPERSED POLYETHYLENE GLYCOL, METHODS FOR PRODUCING SAME, AND HETERO TYPE MONODISPERSED POLYETHYLENE GLYCOL CONJUGATE
(FR) POLYÉTHYLÈNEGLYCOL MONODISPERSÉ DE TYPE HÉTÉRO, INTERMÉDIAIRE POUR LA PRODUCTION DE POLYÉTHYLÈNEGLYCOL MONODISPERSÉ DE TYPE HÉTÉRO, PROCÉDÉS POUR LEUR PRÉPARATION ET CONJUGUÉ DE POLYÉTHYLÈNEGLYCOL MONODISPERSÉ DE TYPE HÉTÉRO
(JA) ヘテロ型単分散ポリエチレングリコール、ヘテロ型単分散ポリエチレングリコール製造用中間体及びそれらの製造方法、並びに、ヘテロ型単分散ポリエチレングリコール結合体
Abstract:
(EN) Provided is a hetero type monodispersed polyethylene glycol which contains a compound represented by formula (1) ( (1): NH2-(CH2CH2O)a-CH2CH2COOH (in formula (1), a is an integer between 6 and 40)) and in which the following each satisfy a specified relational expression: (A) a chromatogram detected by a differential refractometer when separation is carried out using reversed phase chromatography; (B) a chromatogram detected by a differential refractometer when separation is carried out using cation exchange chromatography; and (C) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol containing a compound represented by formula (1) is derivatized and separation is carried out using anion exchange chromatography.
(FR) L'invention concerne un polyéthylèneglycol monodispersé de type hétéro, qui contient un composé représenté par la formule (1) ((1) : NH2-(CH2CH2O)a-CH2CH2COOH (dans la formule (1), a représente un nombre entier compris entre 6 et 40)) et dans lequel les points suivants satisfont chacun à une expression relationnelle spécifiée : (A) un chromatogramme détecté par un réfractomètre différentiel lorsque la séparation est effectuée à l'aide de la chromatographie en phase inverse; (B) un chromatogramme détecté par un réfractomètre différentiel lorsque la séparation est effectuée par l'utilisation de la chromatographie par échange cationique; et (C) un chromatogramme détecté par un réfractomètre différentiel lorsque le polyéthylèneglycol monodispersé de type hétéro contenant un composé représenté par la formule (1) est dérivé et la séparation est effectuée à l'aide de la chromatographie par échange anionique.
(JA) 下記式(1): NH-(CHCHO)-CHCHCOOH ・・・(1) [式(1)中、aは6~40の整数を示す。] で表される化合物を含有するヘテロ型単分散ポリエチレングリコールにおいて、(A)逆相クロマトグラフィーを用いて分離したときの示差屈折率計で検出されるクロマトグラム、(B)陽イオン交換クロマトグラフィーを用いて分離したときの示差屈折率計で検出されるクロマトグラム、及び、(C)前記式(1)で表される化合物を含有するヘテロ型単分散ポリエチレングリコールを誘導体化して陰イオン交換クロマトグラフィーを用いて分離したときの示差屈折率計で検出されるクロマトグラムが、いずれも特定の関係式を満たすヘテロ型単分散ポリエチレングリコール。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
CA2991011KR1020180022919EP3318591US20180186931