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1. WO2016200939 - RADIOFLUORINATED 7-AMINO-5-THIO-THIAZOLO[4,5-D]PYRIMIDINES FOR IMAGING FRACTALKINE RECEPTOR (CX3CR1)

Publication Number WO/2016/200939
Publication Date 15.12.2016
International Application No. PCT/US2016/036447
International Filing Date 08.06.2016
IPC
C07D 513/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
CPC
A61K 51/0459
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
041Heterocyclic compounds
044having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
0459having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
C07D 513/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • THE JOHNS HOPKINS UNIVERSITY [US]/[US]
Inventors
  • POMPER, Martin G.
  • MEASE, Ronnie C.
  • YANG, Xing
  • FOSS, Catherine
Agents
  • CHILDERS, Jeffrey W.
Priority Data
62/172,54708.06.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RADIOFLUORINATED 7-AMINO-5-THIO-THIAZOLO[4,5-D]PYRIMIDINES FOR IMAGING FRACTALKINE RECEPTOR (CX3CR1)
(FR) 7-AMINO-5-THIO-THIAZOLO[4,5-D]PYRIMIDINES RADIOFLUORÉES À UTILISER POUR IMAGER UN RÉCEPTEUR DE LA FRACTALKINE (CX3CR1)
Abstract
(EN)
Radiofluorinated 7-Amino-5-thio-thiazolo[4,5-d]pyrimidines targeting Fractalkine Receptor (CX3CR1) are disclosed. Methods of imaging CX3CR1-expressing tumors or cells also are disclosed.
(FR)
L'invention concerne des 7-Amino-5-thio-thiazolo[4,5-d]pyrimidines radiofluorées ciblant le récepteur de la fractalkine (CX3CR1). L'invention concerne également des méthodes d'imagerie de tumeurs ou de cellules exprimant CX3CR1.
Also published as
Latest bibliographic data on file with the International Bureau