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1. (WO2016196961) LIGANDS SELECTIVE TO ALPHA 6 SUBUNIT-CONTAINING GABAA RECEPTORS ANS THEIR METHODS OF USE

Pub. No.:    WO/2016/196961    International Application No.:    PCT/US2016/035761
Publication Date: Fri Dec 09 00:59:59 CET 2016 International Filing Date: Sat Jun 04 01:59:59 CEST 2016
IPC: C07D 471/04
C07D 471/14
C07D 401/04
C07D 403/04
A61K 31/437
A61K 31/4375
A61K 31/4439
Applicants: UWM RESEARCH FOUNDATION, INC.
MEDICAL UNIVERSITY OF VIENNA
NATIONAL TAIWAN UNIVERSITY
UNIVERSITY OF BELGRADE-FACULTY OF PHARMACY
Inventors: CHIOU, Lih-Chu
COOK, James
ERNST, Margot
FAN, Pi-Chuan
KNUTSON, Daniel
MEIRELLES, Matheus
MIHOVILOVIC, Marko
SIEGHART, Werner
VARAGIC, Zdravko
VERMA, Ranjit
WIMMER, Laurin
WITZIGMANN, Christopher
SIEBERT, David, Chan Bodin
SAVIC, Miroslav, M.
Title: LIGANDS SELECTIVE TO ALPHA 6 SUBUNIT-CONTAINING GABAA RECEPTORS ANS THEIR METHODS OF USE
Abstract:
Provided herein are novel pyrazoloquinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis;depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.