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1. WO2016189486 - AN IMPROVED PROCESS FOR PREPARATION OF APREMILAST AND NOVEL POLYMORPHS THEREOF

Publication Number WO/2016/189486
Publication Date 01.12.2016
International Application No. PCT/IB2016/053083
International Filing Date 26.05.2016
IPC
C07D 209/48 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
48with oxygen atoms in positions 1 and 3, e.g. phthalimide
C07C 315/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
315Preparation of sulfones; Preparation of sulfoxides
04by reactions not involving the formation of sulfone or sulfoxide groups
C07C 317/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
26having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
28with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
CPC
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07B 2200/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
07Optical isomers
C07C 315/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
315Preparation of sulfones; Preparation of sulfoxides
04by reactions not involving the formation of sulfone or sulfoxide groups
C07D 209/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
48with oxygen atoms in positions 1 and 3, e.g. phthalimide
Applicants
  • LUPIN LIMITED [IN]/[IN]
Inventors
  • SANPHUI, Palash
  • SAPDHARE, Ananda, Pundlik
  • PATIL, Arunkumar, Digambar
  • LANDE, Hemraj, Mahadeorao
  • SINGH, Gurvinder, Pal
  • RAY, Purna, Chandra
  • BHISE, Nandu, Baban
  • SINGH, Girij, Pal
  • SURWASE, Mithun, Dasharath
  • VARADE, Shantanu, Gokuldas
  • AUSEKAR, Govind, Dnyanoba
  • SHIVDAVKAR, Radhakrishna, Bhikaji
Agents
  • MAJUMDAR, Subhatosh
  • GANGULI, Dr., Sanchita
  • SEN, Abhishek
  • VENKATESH, Mythili
  • MAJUMDAR, Amrita
  • KUNDU, Subarna
  • CHAUBEY, Priyanka
Priority Data
2046/MUM/201526.05.2015IN
2048/MUM/201526.05.2015IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AN IMPROVED PROCESS FOR PREPARATION OF APREMILAST AND NOVEL POLYMORPHS THEREOF
(FR) PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION D'APRÉMILAST ET DE NOUVEAUX POLYMORPHES DE CELUI-CI
Abstract
(EN)
The present invention provides an improved process for preparation of an intermediate of apremilast. The present invention also provides an improved process for preparation of apremilast. This invention also provides novel polymorphs of apremilast. The present invention also provides pharmaceutical compositions of novel polymorphs of apremilast. This invention also provides a process for preparation of novel polymorphs of apremilast, which are cost-effective, robust, and viable at plant scale.
(FR)
La présente invention porte sur un procédé amélioré pour la préparation d'un intermédiaire d'aprémilast. La présente invention concerne également un procédé amélioré de préparation d'aprémilast. L'invention concerne aussi de nouveaux polymorphes d'aprémilast. La présente invention concerne en outre des compositions pharmaceutiques de nouveaux polymorphes d'aprémilast. L'invention concerne également un procédé de préparation de nouveaux polymorphes d'aprémilast qui sont rentables, robustes, et viables à l'échelle industrielle.
Latest bibliographic data on file with the International Bureau