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1. WO2016189011 - HETEROCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Publication Number WO/2016/189011
Publication Date 01.12.2016
International Application No. PCT/EP2016/061733
International Filing Date 25.05.2016
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
044
with only one oxygen atom as ring hetero atom in the oxygen-containing ring
052
the oxygen-containing ring being six-membered
C07D 405/14 (2006.01)
C07D 405/04 (2006.01)
C07D 405/12 (2006.01)
C07D 491/052 (2006.01)
CPC
A61K 31/397
A61K 31/416
A61K 31/4162
A61K 31/4439
A61K 31/497
C07D 405/04
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (US)
Inventors
  • GOODACRE, Simon Charles; GB
  • GOVEK, Steven P.; US
  • KAHRAMAN, Mehmet; US
  • LABADIE, Sharada; US
  • LAI, Andiliy G.; US
  • LIANG, Jun; US
  • NAGASAWA, Johnny Y.; US
  • ORTWINE, Daniel Fred; US
  • RAY, Nicholas Charles; GB
  • SMITH, Nicholas D.; US
  • WANG, Xiaojing; US
  • ZHANG, Birong; US
Agents
  • HAEFELE RACIN, Thomas; CH
Priority Data
62/166,36026.05.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HETEROCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
(FR) MODULATEURS DES RÉCEPTEURS D’ŒSTROGÈNES HÉTÉROCYCLIQUES ET LEURS UTILISATIONS
Abstract
(EN)
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
(FR)
Cette invention concerne des composés qui sont des modulateurs des récepteurs d'œstrogènes. Cette invention concerne également des compositions pharmaceutiques et des médicaments contenant lesdits composés, ainsi que des procédés d'utilisation desdits modulateurs des récepteurs d'œstrogènes, seuls ou en association avec d'autres composés, pour traiter des maladies ou des troubles qui sont médiés par des récepteurs d'œstrogènes ou qui dépendent de tels récepteurs.
Also published as
Latest bibliographic data on file with the International Bureau