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1. (WO2016187157) USE OF PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR TREATMENT OF VASCULAR MALFORMATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/187157    International Application No.:    PCT/US2016/032779
Publication Date: 24.11.2016 International Filing Date: 16.05.2016
IPC:
A61K 38/00 (2006.01), C07K 2/00 (2006.01), C12Q 1/68 (2006.01)
Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER [US/US]; 1275 York Avenue New York, NY 10065 (US)
Inventors: BASELGA, Eulalia; (ES).
CASTEL, Pau; (US).
BASELGA, Jose, T.; (US)
Agent: BISSONNETTE, Dennis, M.; (US)
Priority Data:
62/162,534 15.05.2015 US
62/313,476 25.03.2016 US
62/265,641 10.12.2015 US
Title (EN) USE OF PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR TREATMENT OF VASCULAR MALFORMATIONS
(FR) UTILISATION D'INHIBITEURS DE PHOSPHOINOSITIDE 3-KINASE POUR LE TRAITEMENT DE MALFORMATIONS VASCULAIRES
Abstract: front page image
(EN)The present invention relates to methods of treating a vascular malformation in a subject expressing a gain-of-function mutation in a PIK3CA gene comprising administering, to the subject, an effective amount of an agent that inhibits phosphoinositide 3-kinase ("PI3K").
(FR)La présente invention concerne des méthodes de traitement d'une malformation vasculaire chez un sujet exprimant une mutation gain-de-fonction dans un gène PIK3CA qui consistent à administrer au sujet une dose efficace d'un agent qui inhibe la phosphoinositide 3-kinase ('PI3K").
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)