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1. (WO2016187073) METHODS FOR IMMUNIZING AGAINST CLOSTRIDIUM DIFFICILE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/187073    International Application No.:    PCT/US2016/032568
Publication Date: 24.11.2016 International Filing Date: 14.05.2016
IPC:
A61K 39/08 (2006.01)
Applicants: SANOFI PASTEUR INC. [US/US]; One Discovery Drive Swiftwater, PA 18017 (US)
Inventors: QUEMENEUR, Laurence; (FR).
PIETROBON, Patricia, J.; (US).
LONDONO-HAYES, Patricia; (FR).
HAUSER, Steven; (US)
Agent: HALLORAN, Patrick, J.; (US)
Priority Data:
62/162,357 15.05.2015 US
Title (EN) METHODS FOR IMMUNIZING AGAINST CLOSTRIDIUM DIFFICILE
(FR) PROCÉDÉS D'IMMUNISATION CONTRE LE CLOSTRIDIUM DIFFICILE
Abstract: front page image
(EN)The disclosure relates to generally to the field of therapeutic and/or protective vaccination against Clostridium dificile (C. difficile). More specifically, it relates to methods for immunizing a host against C. difficile strains expressing C. difficile binary toxin (CDT) and strains not expressing CDT. These methods involve the administration to a host of an immunogenic composition comprising inactivated purified C. difficile Toxin A and purified Toxin B. The purified C. difficile toxins may be derived from a C. difficile strain that does not express CDT.
(FR)La présente invention concerne de manière générale le domaine de la vaccination thérapeutique et/ou protectrice contre le Clostridium difficile (C. difficile). Plus spécifiquement, la présente invention concerne des procédés pour immuniser un hôte contre des souches de C. difficile exprimant une toxine binaire de C. difficile (CDT) et des souches qui n'expriment pas CDT. Ces procédés impliquent l'administration, à un hôte, d'une composition immunogène comprenant une toxine A de C. difficile purifiée inactivée et une toxine B purifiée. Les toxines de C. difficile purifiées peuvent être obtenues à partir d'une souche de C. difficile qui n'exprime pas CDT.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)