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1. (WO2016187030) NOVEL METHYLATION SITE REGULATING EXPRESSION OF MDA-9/SYNTENIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/187030    International Application No.:    PCT/US2016/032431
Publication Date: 24.11.2016 International Filing Date: 13.05.2016
IPC:
C07H 21/00 (2006.01), C12Q 1/68 (2006.01), G01N 33/48 (2006.01)
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY [US/US]; 800 East Leigh Street Suite 3000 Richmond, VA 23298 (US)
Inventors: FISHER, Paul, B.; (US).
BACOLOD, Manny; (US)
Agent: WHITHAM, Michael, E.; (US)
Priority Data:
62/162,213 15.05.2015 US
Title (EN) NOVEL METHYLATION SITE REGULATING EXPRESSION OF MDA-9/SYNTENIN
(FR) NOUVEAU SITE DE MÉTHYLATION RÉGULANT L'EXPRESSION DU GÈNE MDA-9/SYNTÉNINE
Abstract: front page image
(EN)Methods of prognosing the outcome of cancer and/or cancer treatment are provided. The methods involve qiiantitating the level of methylation at a site that regulates expression of the mda-9/Syntenin gene, site cgl 7197774. High levels of methylation indicate a good prognosis whereas low levels of methylation indicate a poor prognosis and determination of these levels permits risk stratification of patients with cancer.
(FR)L'invention concerne des procédés de pronostic de l'issue d'un cancer et/ou du traitement d'un cancer. Ces procédés consistent à quantifier le niveau de méthylation au niveau d'un site qui régule l'expression du gène mda-9/synténine, le site cgl 7197774. Des niveaux élevés de méthylation indiquent un bon pronostic, tandis que de faibles niveaux de méthylation indiquent un mauvais pronostic, et la détermination de ces niveaux permet la stratification du risque chez les patients atteints d'un cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)