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1. (WO2016186853) METHODS OF TARGETING APE1/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/186853    International Application No.:    PCT/US2016/030904
Publication Date: 24.11.2016 International Filing Date: 05.05.2016
IPC:
A61K 31/192 (2006.01), A61K 31/00 (2006.01), A61K 31/122 (2006.01)
Applicants: INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION [US/US]; 518 Indiana Ave. Indianapolis, Indiana 46202 (US)
Inventors: KELLEY, Mark R.; (US).
FISHEL, Melissa; (US)
Agent: BOETTLER, Jeannie M.; (US)
Priority Data:
62/164,795 21.05.2015 US
62/307,000 11.03.2016 US
Title (EN) METHODS OF TARGETING APE1/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES
(FR) PROCÉDÉS DE CIBLAGE D'APE1/REF -1 POUR INHIBER LES GÈNES DE SIGNALISATION DE L'HYPOXIE
Abstract: front page image
(EN)Methods for targeting apurinic/apyrimidinic endonuclease1/redox effector factor 1 (APEl/Ref-1) are disclosed. More particularly, methods for inhibiting APEl/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.
(FR)La présente invention concerne des procédés de ciblage du facteur effecteur 1 endonucléase1/redox apurinique/apyrimidinique (APEl/Ref -1). Plus particulièrement, l'invetion porte sur des procédés d'inhibition de APEl/Ref -1 et de la signalisation induite par l'hypoxie pour diminuer la survie et l'invasion de cellules tumorales exposées à des conditions hypoxiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)